Discriminating between cellular and misfolded prion protein by using affinity to 9-aminoacridine compounds.

Abstract

Quinacrine and related 9-aminoacridine compounds are effective in eliminating the alternatively folded prion protein, termed PrP(Sc), from scrapie-infected cultured cells. Clinical evaluations of quinacrine for the treatment of human prion diseases are progressing in the absence of a clear understanding of the molecular mechanism by which prion replication… (More)

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@article{Phuan2007DiscriminatingBC, title={Discriminating between cellular and misfolded prion protein by using affinity to 9-aminoacridine compounds.}, author={Puay-Wah Phuan and Julie Anne Zorn and Jiri G Safar and Kurt Giles and Stanley B Prusiner and Fred E. Cohen and Barnaby C. H. May}, journal={The Journal of general virology}, year={2007}, volume={88 Pt 4}, pages={1392-401} }