Discriminating Protective from Nonprotective Plasmodium-Specific CD8+ T Cell Responses.

  title={Discriminating Protective from Nonprotective Plasmodium-Specific CD8+ T Cell Responses.},
  author={Katherine L. Doll and Lecia L. Pewe and Samarchith P. Kurup and John T Harty},
  journal={Journal of immunology},
  volume={196 10},
Despite decades of research, malaria remains a global health crisis. Current subunit vaccine approaches do not provide efficient long-term, sterilizing immunity against Plasmodium infections in humans. Conversely, whole parasite vaccinations with their larger array of target Ags have conferred long-lasting sterilizing protection to humans. Similar studies in rodent models of malaria reveal that CD8(+) T cells play a critical role in liver-stage immunity after whole parasite vaccination. However… CONTINUE READING
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