Discriminating D-amino acid-containing peptide epimers by radical-directed dissociation mass spectrometry.

@article{Tao2012DiscriminatingDA,
  title={Discriminating D-amino acid-containing peptide epimers by radical-directed dissociation mass spectrometry.},
  author={Yuanqi Tao and Neil R Quebbemann and Ryan R Julian},
  journal={Analytical chemistry},
  year={2012},
  volume={84 15},
  pages={6814-20}
}
The presence of a single D-amino acid in a peptide is very difficult to detect. Mass spectrometry-based approaches rely on differences in fragmentation between all L-amino acid-containing peptides and single D-amino acid-containing peptides (which are epimers) for identification. The success of this approach is dependent on the structural sensitivity of the fragmentation method. Recently, experiments have demonstrated that fragmentation initiated by radical chemistry, or radical-directed… CONTINUE READING

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