Discriminated selection among viral peptides with the appropriate anchor residues: implications for the size of the cytotoxic T-lymphocyte repertoire and control of viral infection.

@article{Oldstone1995DiscriminatedSA,
  title={Discriminated selection among viral peptides with the appropriate anchor residues: implications for the size of the cytotoxic T-lymphocyte repertoire and control of viral infection.},
  author={Michael B A Oldstone and H. Andy Podgurski Michael Lewicki and Persephone Borrow and Denis Hudrisier and Jean Edouard Gairin},
  journal={Journal of virology},
  year={1995},
  volume={69 12},
  pages={7423-9}
}
Structural characterization of peptides restricted by major histocompatibility complex (MHC) class I molecules has identified residues critical for MHC class I binding and for T-cell receptor recognition. For example, optimal peptides fitting into the murine MHC class I Db groove are 9 to 11 amino acids long and require as MHC anchor residues an Asn (N) at position 5 and also either a hydrophobic residue, a Met (M) or a Cys (C), at the carboxy terminus. The three known Db-restricted peptides of… CONTINUE READING