Discriminant analysis as a tool to identify compounds with potential as transdermal enhancers.

@article{Pugh2005DiscriminantAA,
  title={Discriminant analysis as a tool to identify compounds with potential as transdermal enhancers.},
  author={Williamson Pugh and Rosemary Wong and Françoise Falson and Bozena Michniak and Gary Patrick Moss},
  journal={The Journal of pharmacy and pharmacology},
  year={2005},
  volume={57 11},
  pages={1389-96}
}
Structure-activity relationships were sought for 73 enhancers of hydrocortisone permeation from propylene glycol across hairless mouse skin. Enhancers had chain lengths (CC) from 0 to 16 carbon atoms, 1 to 8 H-bonding atoms (HB), molecular weight 60 to 450, log P (calculated) -1.7 to 9.7 and log S (calculated) -7.8 to 0.7. These predictive properties were chosen because of their ready availability. Enhancement ratio (ER) was defined as hydrocortisone transferred after 24 h relative to control… CONTINUE READING