Discrete signaling pathways participate in RB-dependent responses to chemotherapeutic agents

@article{Mayhew2004DiscreteSP,
  title={Discrete signaling pathways participate in RB-dependent responses to chemotherapeutic agents},
  author={Christopher N. Mayhew and Lisa M Perkin and Xiaoping Zhang and Julien Sage and Tyler 8 Jacks and Erik S. Knudsen},
  journal={Oncogene},
  year={2004},
  volume={23},
  pages={4107-4120}
}
The retinoblastoma (RB) tumor suppressor has been proposed to function as a key mediator of cell cycle checkpoints induced by chemotherapeutic agents. However, these prior studies have relied on embryonic fibroblasts harboring chronic loss of RB, a condition under which compensation of RB functions is known to occur. Here we utilized primary adult fibroblasts derived from mice harboring loxP sites flanking exon 3 of the Rb gene to delineate the action of RB in the chemotherapeutic response. In… CONTINUE READING

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