Discrete serum protein signatures discriminate between human retrovirus-associated hematologic and neurologic disease

@article{Semmes2005DiscreteSP,
  title={Discrete serum protein signatures discriminate between human retrovirus-associated hematologic and neurologic disease},
  author={O. John Semmes and Lisa H. Cazares and Michael D. Ward and Lining Qi and Mariama Moody and Eileen K Maloney and John P. Morris and Michael W. Trosset and Michie Hisada and Steven Gygi and Steve Jacobson},
  journal={Leukemia},
  year={2005},
  volume={19},
  pages={1229-1238}
}
The human T-cell leukemia virus type I (HTLV-I) is the causative agent for adult T-cell leukemia (ATL) and HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Approximately 5% of infected individuals will develop either disease and currently there are no diagnostic tools for early detection or accurate assessment of disease state. We have employed high-throughput expression profiling of serum proteins using mass spectrometry to identify protein expression patterns that can… CONTINUE READING