Discrete roles of STAT4 and STAT6 transcription factors in tuning epigenetic modifications and transcription during T helper cell differentiation.

@article{Wei2010DiscreteRO,
  title={Discrete roles of STAT4 and STAT6 transcription factors in tuning epigenetic modifications and transcription during T helper cell differentiation.},
  author={Lai Wei and Golnaz Vahedi and Hong-wei Sun and Wendy T Watford and Hiroaki Takatori and Hayde{\'e} L. Ramos and Hayato Takahashi and Jonathan Glover Yuji Ijiri Carolyn Levine Pierre Liang and Gustavo Gutierrez-Cruz and Chongzhi Zang and Weiqun Peng and John J O'Shea and Yuka Kanno},
  journal={Immunity},
  year={2010},
  volume={32 6},
  pages={840-51}
}
Signal transducer and activator of transcription 4 (STAT4) and STAT6 are key factors in the specification of helper T cells; however, their direct roles in driving differentiation are not well understood. Using chromatin immunoprecipitation and massive parallel sequencing, we quantitated the full complement of STAT-bound genes, concurrently assessing global STAT-dependent epigenetic modifications and gene transcription by using cells from cognate STAT-deficient mice. STAT4 and STAT6 each bound… CONTINUE READING
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