Discrete enhancer elements mediate selective responsiveness of enhancer of split complex genes to common transcriptional activators.

@article{Nellesen1999DiscreteEE,
  title={Discrete enhancer elements mediate selective responsiveness of enhancer of split complex genes to common transcriptional activators.},
  author={D T Nellesen and Eric C. Lai and James W Posakony},
  journal={Developmental biology},
  year={1999},
  volume={213 1},
  pages={33-53}
}
In Drosophila, genes of the Enhancer of split Complex [E(spl)-C] are important components of the Notch (N) cell-cell signaling pathway, which is utilized in imaginal discs to effect a series of cell fate decisions during adult peripheral nervous system development. Seven genes in the complex encode basic helix-loop-helix (bHLH) transcriptional repressors, while 4 others encode members of the Bearded family of small proteins. A striking diversity is observed in the imaginal disc expression… CONTINUE READING

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