Discrete-Event Models of Mixed-Phenotype Plasmodium falciparum Malaria


We extend our basic discrete-event model of Plasmodium falciparum malaria to encompass circumstances in which multiple phenotypic variants of the parasite circulate within interacting human and mosquito populations, and we compare a version in which variants behave independently to one in which they interact through shared host immune responses. Relative to the standard hypothesis of statistical independence, frequencies of mixed-phenotype infection in humans were as expected in the independent-immunity version and much less than expected in the cross-immunity version; in both versions, however, such frequencies in mosquitoes were much greater than expected.

DOI: 10.1177/003754979907300403

Cite this paper

@article{McKenzie1999DiscreteEventMO, title={Discrete-Event Models of Mixed-Phenotype Plasmodium falciparum Malaria}, author={F. Ellis McKenzie and Roger C. Wong and William H. Bossert}, journal={Simulation}, year={1999}, volume={73 4}, pages={213-217} }