Discrepant Effects of Human Interferon-gamma on Clinical and Immunological Disease Parameters in a Novel Marmoset Model for Multiple Sclerosis

@inproceedings{Jagessar2011DiscrepantEO,
  title={Discrepant Effects of Human Interferon-gamma on Clinical and Immunological Disease Parameters in a Novel Marmoset Model for Multiple Sclerosis},
  author={S Anwar Jagessar and Bruno Gran and Nicole Heijmans and Jan Bauer and Jon D Laman and Bert Adriaan ‘t Hart and Cris S. Constantinescu},
  booktitle={Journal of Neuroimmune Pharmacology},
  year={2011}
}
The core pathogenic process in the common marmoset model of multiple sclerosis (MS) is the activation of memory-like T cells specific for peptide 34 to 56 derived from the extracellular domain of myelin/oligodendrocyte glycoprotein (MOG34-56). Immunization with MOG34-56 in incomplete Freund’s adjuvant is a sufficient stimulus for in vivo activation of these T cells, together with the induction of MS-like disease and CNS pathology. Ex vivo functional characteristics of MOG34-56 specific T cells… CONTINUE READING
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