Discrepancy between Bioavailability and Hypotensive Effect of Oral and Sublingual Nifedipine.

@article{PalmaAguirre1995DiscrepancyBB,
  title={Discrepancy between Bioavailability and Hypotensive Effect of Oral and Sublingual Nifedipine.},
  author={Jos{\'e} Antonio Palma-Aguirre and Miguel A Montoya-Cabrera and Patrick du Souich and C. Hoyo-Vadillo and Francisco Javier Flores-Murrieta and Gilberto Casta{\~n}eda-Hern{\'a}ndez},
  journal={American journal of therapeutics},
  year={1995},
  volume={2 1},
  pages={3-9}
}
Nifedipine, 10-mg capsules, were given orally and sublingually to six healthy volunteers according to a randomized crossover design. Nifedipine plasma levels, blood pressure, and heart rate were determined at several times after medication. C(max) was higher (134 plus minus 17 vs. 93 plus minus 2 ng ml(minus sign1), mean plus minus SD, P < 0.01) and occurred earlier (0.5 vs. 1 h) with oral than with sublingual nifedipine. However, there was no significant difference in AUC (268 plus minus 56 vs… CONTINUE READING

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