Discovery that a melanocortin regulates sexual functions in male and female humans

  title={Discovery that a melanocortin regulates sexual functions in male and female humans},
  author={Mac E. Hadley},
  • M. Hadley
  • Published 2005
  • Biology, Medicine
  • Peptides
Melanocortins (MCs) are multifunctional peptide hormones that regulate a diversity of physiological functions. MCs have been implicated in sexual function in animals. We document here that a MC analog, Melanotan II (MTII), can enhance sexual function in human males (erectile activity) and females (increased levels of sexual desire and genital arousal). Unlike other sexual-enhancement drugs, MTII works at the level of the brain, thus eliciting a rather natural sexual response with minimal or no… Expand
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Pathways of sexual desire.
  • J. Pfaus
  • Psychology, Medicine
  • The journal of sexual medicine
  • 2009
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Melanocortin receptor agonists, penile erection, and sexual motivation: human studies with Melanotan II
It is concluded that Melanotan II is a potent initiator of penile erection in men with erectile dysfunction and warrant further investigation of melanocortin agonists and antagonists onPenile erection. Expand
Coat color darkening in a dog in response to a potent melanotropic peptide.
Observations clearly indicated that follicular melanogenesis can be induced in dogs by treatment with a melanotropic peptide. Expand
Effect of an alpha-melanocyte stimulating hormone analog on penile erection and sexual desire in men with organic erectile dysfunction.
The erectogenic properties of Melanotan II are not limited to cases of psychogenic erectile dysfunction; men with a variety of organic risk factors developed penile erections and the finding of increased sexual desire warrants further investigation of centrally acting agents on disorders of sexual desire. Expand
Mutations in the Human Proopiomelanocortin Gene
Patients with a complete defect of the POMC gene product due to homozygous or compound heterozygous loss of function mutations were shown to be affected mainly by red hair, early‐onset obesity, and congenital hypocortisolism, suggesting no additional function of the melanocortin system has escaped recognition. Expand
Facilitation and inhibition of sexual receptivity in the female rat by α-MSH
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Synthetic melanotropic peptide initiates erections in men with psychogenic erectile dysfunction: double-blind, placebo controlled crossover study.
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Potent and prolonged acting cyclic lactam analogues of alpha-melanotropin: design based on molecular dynamics.
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