Discovery that a melanocortin regulates sexual functions in male and female humans

@article{Hadley2005DiscoveryTA,
  title={Discovery that a melanocortin regulates sexual functions in male and female humans},
  author={Mac E. Hadley},
  journal={Peptides},
  year={2005},
  volume={26},
  pages={1687-1689}
}
  • M. Hadley
  • Published 2005
  • Biology, Medicine
  • Peptides
Melanocortins (MCs) are multifunctional peptide hormones that regulate a diversity of physiological functions. MCs have been implicated in sexual function in animals. We document here that a MC analog, Melanotan II (MTII), can enhance sexual function in human males (erectile activity) and females (increased levels of sexual desire and genital arousal). Unlike other sexual-enhancement drugs, MTII works at the level of the brain, thus eliciting a rather natural sexual response with minimal or no… Expand
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References

SHOWING 1-10 OF 12 REFERENCES
PT‐141: A Melanocortin Agonist for the Treatment of Sexual Dysfunction
TLDR
PT‐141, a synthetic peptide analogue of α‐MSH, is an agonist at melanocortin receptors including the MC3R and MC4R, which are expressed primarily in the central nervous system, which suggests that PT‐141 holds promise as a new treatment for sexual dysfunction. Expand
Melanocortin receptor agonists, penile erection, and sexual motivation: human studies with Melanotan II
TLDR
It is concluded that Melanotan II is a potent initiator of penile erection in men with erectile dysfunction and warrant further investigation of melanocortin agonists and antagonists onPenile erection. Expand
Coat color darkening in a dog in response to a potent melanotropic peptide.
TLDR
Observations clearly indicated that follicular melanogenesis can be induced in dogs by treatment with a melanotropic peptide. Expand
Effect of an alpha-melanocyte stimulating hormone analog on penile erection and sexual desire in men with organic erectile dysfunction.
TLDR
The erectogenic properties of Melanotan II are not limited to cases of psychogenic erectile dysfunction; men with a variety of organic risk factors developed penile erections and the finding of increased sexual desire warrants further investigation of centrally acting agents on disorders of sexual desire. Expand
Mutations in the Human Proopiomelanocortin Gene
TLDR
Patients with a complete defect of the POMC gene product due to homozygous or compound heterozygous loss of function mutations were shown to be affected mainly by red hair, early‐onset obesity, and congenital hypocortisolism, suggesting no additional function of the melanocortin system has escaped recognition. Expand
Facilitation and inhibition of sexual receptivity in the female rat by α-MSH
Abstract The effect of α-MSH on sexual behaviour was examined in female rats. Ovariectomized rats received 2 μg oestradiol benzoate on Day 1 and on Day 3 an injection of progesterone. Four hoursExpand
Synthetic melanotropic peptide initiates erections in men with psychogenic erectile dysfunction: double-blind, placebo controlled crossover study.
TLDR
Melanotan-II is a potent initiator of erections in men with psychogenic erectile dysfunction and has manageable side effects at a dose of 0.025 mg./kg. Expand
Yawning and Penile Erection: Central Dopamine‐Oxytocin‐Adrenocorticotropin Connection a
TLDR
Evidence is provided for the first time that DA, oxytocin, and ACTH act in the hypothalamus in a sequence to induce these behavioral responses to yawning and penile erection. Expand
Effects of a superpotent melanotropic peptide in combination with solar UV radiation on tanning of the skin in human volunteers.
TLDR
Melanotan-1 can be safely combined with UV-B light or sunlight and appears to act synergistically in the tanning response to light. Expand
Potent and prolonged acting cyclic lactam analogues of alpha-melanotropin: design based on molecular dynamics.
TLDR
New insights are provided into the structural and conformational requirements of alpha-MSH and its analogues at two different types of pigment cell (melanocyte) receptors. Expand
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