Discovery of zoniporide: a potent and selective sodium-hydrogen exchanger type 1 (NHE-1) inhibitor with high aqueous solubility.

Abstract

Zoniporide (CP-597,396) is a potent and selective inhibitor of NHE-1, which exhibits high aqueous solubility and acceptable pharmacokinetics for intravenous administration. The discovery, synthesis, activities, and rat and dog pharmacokinetics of this compound are presented. The potency and selectivity of zoniporide may be due to the conformation that the… (More)

Topics

Cite this paper

@article{GuzmanPerez2001DiscoveryOZ, title={Discovery of zoniporide: a potent and selective sodium-hydrogen exchanger type 1 (NHE-1) inhibitor with high aqueous solubility.}, author={Angel Guzman-Perez and Ronald T Wester and Matt C Allen and Julien A Brown and Allan R Buchholz and Ewell R Cook and Wesley W. Day and Ernest S Hamanaka and Scott P Kennedy and Delvin R. Knight and P. J. Kowalczyk and Ravi B. Marala and Christian J Mularski and W A Novomisle and Roger B Ruggeri and William R. Tracey and Roger J Hill}, journal={Bioorganic & medicinal chemistry letters}, year={2001}, volume={11 6}, pages={803-7} }