Discovery of zoniporide: a potent and selective sodium-hydrogen exchanger type 1 (NHE-1) inhibitor with high aqueous solubility.

@article{GuzmanPerez2001DiscoveryOZ,
  title={Discovery of zoniporide: a potent and selective sodium-hydrogen exchanger type 1 (NHE-1) inhibitor with high aqueous solubility.},
  author={Angel Guzman-Perez and Ronald T Wester and Mary C Allen and Julien A Brown and Allan R Buchholz and Ewell R Cook and Wesley W. Day and Ernest S Hamanaka and Scott P. Kennedy and Delvin R. Knight and P. J. Kowalczyk and Ravi B. Marala and Christian J Mularski and W A Novomisle and Roger B. Ruggeri and W. Ross Tracey and Roger J. Hill},
  journal={Bioorganic & medicinal chemistry letters},
  year={2001},
  volume={11 6},
  pages={803-7}
}
Zoniporide (CP-597,396) is a potent and selective inhibitor of NHE-1, which exhibits high aqueous solubility and acceptable pharmacokinetics for intravenous administration. The discovery, synthesis, activities, and rat and dog pharmacokinetics of this compound are presented. The potency and selectivity of zoniporide may be due to the conformation that the molecule adopts due to the presence of a cyclopropyl and a 5-quinolinyl substituent on the central pyrazole ring of the molecule.