Discovery of thieno[2,3-c]pyridines as potent COT inhibitors.

Abstract

Evaluation of hit chemotypes from high throughput screening identified a novel series of 2,4-disubstituted thieno[2,3-c]pyridines as COT kinase inhibitors. Structural modifications exploring SAR at the 2- and 4-positions resulting in inhibitors with improved enzyme potency and cellular activity are disclosed. 
DOI: 10.1016/j.bmcl.2008.08.037

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