Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder

  title={Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder},
  author={Ditte Demontis and Raymond K. Walters and Joanna Martin and Manuel Mattheisen and Thomas Damm Als and Esben Agerbo and G{\'i}sli Baldursson and Richard A. Belliveau and Jonas Bybjerg-Grauholm and Marie B{\ae}kvad-Hansen and Felecia Cerrato and Kimberly Chambert and Claire Churchhouse and Ashle Dumont and Nicholas Eriksson and Michael J. Gandal and Jacqueline I. Goldstein and Katrina L. Grasby and Jakob Grove and Olafur O. Gudmundsson and Christine S{\o}holm Hansen and Mads Engel Hauberg and Mads Vilhelm Hollegaard and Daniel P. Howrigan and Hailiang Huang and Julian B. Maller and Alicia R. Martin and Nicholas G. Martin and Jennifer L. Moran and Jonatan Pallesen and Duncan S. Palmer and Carsten B{\o}cker Pedersen and Marianne Gi{\o}rtz Pedersen and Timothy Poterba and Jesper Buchhave Poulsen and Stephan Ripke and Elise B. Robinson and F. Kyle Satterstrom and Hreinn Stef{\'a}nsson and Christine R. Stevens and Patrick Turley and G. Bragi Walters and Hyejung Won and Margaret J. Wright and Ole Andreas Andreassen and Philip J Asherson and Christie L. Burton and Dorret I. Boomsma and Bru Cormand and S{\o}ren Dalsgaard and Barbara Franke and Joel Gelernter and Daniel H. Geschwind and Hakon H. Hakonarson and Jan Haavik and Henry R. Kranzler and Jonna Kuntsi and Kate Langley and Klaus-Peter Lesch and Christel M. Middeldorp and Andreas Reif and Luis Augusto Rohde and Panos Roussos and Russell J. Schachar and Pamela Sklar and Edmund J. S. Sonuga-Barke and Patrick F. Sullivan and Anita Thapar and Joyce Y. Tung and Irwin D. Waldman and Sarah E. Medland and K{\'a}ri Stef{\'a}nsson and Merete Nordentoft and David Michael Hougaard and Thomas M. Werge and Ole Mors and Preben Bo Mortensen and Mark J. Daly and Stephen V. Faraone and Anders Dupont B{\o}rglum and Benjamin M. Neale},
  journal={Nature Genetics},
Attention deficit/hyperactivity disorder (ADHD) is a highly heritable childhood behavioral disorder affecting 5% of children and 2.5% of adults. Common genetic variants contribute substantially to ADHD susceptibility, but no variants have been robustly associated with ADHD. We report a genome-wide association meta-analysis of 20,183 individuals diagnosed with ADHD and 35,191 controls that identifies variants surpassing genome-wide significance in 12 independent loci, finding important new… 

Shared genetic background between children and adults with attention deficit/hyperactivity disorder

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Identification of risk variants and characterization of the polygenic architecture of disruptive behavior disorders in the context of ADHD

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Epigenome-wide association study of attention-deficit/hyperactivity disorder in adults

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Genetics in the ADHD Clinic: How Can Genetic Testing Support the Current Clinical Practice?

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Recent advances in quantitative and molecular genetic research from the past 5-10 years are summarized to anticipate further success with gene discovery, characterization of how the ADHD phenotype relates to other human traits and growing potential to use genomic risk factors for understanding clinical trajectories and for precision medicine approaches.

Polygenic association between attention-deficit/hyperactivity disorder liability and cognitive impairments

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Identification of genetic overlap and novel risk loci for attention-deficit/hyperactivity disorder and bipolar disorder

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First genetic risk loci for ADHD identified

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The molecular genetic architecture of attention deficit hyperactivity disorder

A state-of-the-art review of the molecular genetics of ADHD incorporating evidence from candidate gene and linkage designs, as well as genome-wide association studies of common single-nucleotide polymorphisms (SNPs) and rare copy number variations (CNVs).

Shared heritability of attention-deficit/hyperactivity disorder and autism spectrum disorder

It is proposed that future studies examining shared familial etiological factors for ADHD and ASD use a family-based design in which the same phenotypic (ADHD and ASD), candidate endophenotypic, and environmental measurements are obtained from all family members.

Molecular Genetics of Attention-Deficit/Hyperactivity Disorder

Shared polygenic contribution between childhood attention-deficit hyperactivity disorder and adult schizophrenia†

Increasing evidence for a small, but significant, shared genetic susceptibility between adult schizophrenia and childhood ADHD highlights the importance of research work across traditional diagnostic boundaries.

High Loading of Polygenic Risk for ADHD in Children With Comorbid Aggression

Common genetic variation is relevant to ADHD, especially in individuals with comorbid aggression, andPolygenic risk for ADHD, derived from the meta-analysis, was higher in the independent ADHD group than in the comparison group.

The genetics of attention deficit/hyperactivity disorder in adults, a review

Progress in identifying aADHD risk genes may provide tools for the prediction of disease progression in the clinic and better treatment, and ultimately may help to prevent persistence of ADHD into adulthood.

Polygenic transmission and complex neuro developmental network for attention deficit hyperactivity disorder: Genome‐wide association study of both common and rare variants

  • Li YangB. Neale Yufeng Wang
  • Biology
    American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
  • 2013
The genetic architecture of ADHD comprises both common and rare variants, and some common causal variants are likely to be shared between Han Chinese and Caucasians.