Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder

@article{Demontis2018DiscoveryOT,
  title={Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder},
  author={Ditte Demontis and Raymond K. Walters and Joanna Martin and Manuel Mattheisen and Thomas Damm Als and Esben Agerbo and G{\'i}sli Baldursson and Richard A. Belliveau and Jonas Bybjerg-Grauholm and Marie B{\ae}kvad-Hansen and Felecia Cerrato and Kimberly Chambert and Claire Churchhouse and Ashle Dumont and Nicholas Eriksson and Michael J. Gandal and Jacqueline I. Goldstein and Katrina L. Grasby and Jakob Grove and Olafur O. Gudmundsson and Christine S{\o}holm Hansen and Mads Engel Hauberg and Mads Vilhelm Hollegaard and Daniel P. Howrigan and Hailiang Huang and Julian B. Maller and Alicia R. Martin and Nicholas G. Martin and Jennifer L. Moran and Jonatan Pallesen and Duncan S. Palmer and Carsten B{\o}cker Pedersen and Marianne Gi{\o}rtz Pedersen and Timothy Poterba and Jesper Buchhave Poulsen and Stephan Ripke and Elise B. Robinson and F. Kyle Satterstrom and Hreinn Stef{\'a}nsson and Christine R. Stevens and Patrick Turley and G. Bragi Walters and Hyejung Won and Margaret J. Wright and Ole Andreas Andreassen and Philip J Asherson and Christie L. Burton and Dorret I. Boomsma and Bru Cormand and S{\o}ren Dalsgaard and Barbara Franke and Joel Gelernter and Daniel H. Geschwind and Hakon H. Hakonarson and Jan Haavik and Henry R. Kranzler and Jonna Kuntsi and Kate Langley and Klaus-Peter Lesch and Christel M. Middeldorp and Andreas Reif and Luis Augusto Rohde and Panos Roussos and Russell J. Schachar and Pamela Sklar and Edmund J. S. Sonuga-Barke and Patrick F. Sullivan and Anita Thapar and Joyce Y. Tung and Irwin D. Waldman and Sarah E. Medland and K{\'a}ri Stef{\'a}nsson and Merete Nordentoft and David Michael Hougaard and Thomas M. Werge and Ole Mors and Preben Bo Mortensen and Mark J. Daly and Stephen V. Faraone and Anders Dupont B{\o}rglum and Benjamin M. Neale},
  journal={Nature Genetics},
  year={2018},
  volume={51},
  pages={63-75}
}
Attention deficit/hyperactivity disorder (ADHD) is a highly heritable childhood behavioral disorder affecting 5% of children and 2.5% of adults. Common genetic variants contribute substantially to ADHD susceptibility, but no variants have been robustly associated with ADHD. We report a genome-wide association meta-analysis of 20,183 individuals diagnosed with ADHD and 35,191 controls that identifies variants surpassing genome-wide significance in 12 independent loci, finding important new… 

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  • Li YangB. Neale Yufeng Wang
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    American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
  • 2013
The genetic architecture of ADHD comprises both common and rare variants, and some common causal variants are likely to be shared between Han Chinese and Caucasians.
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