Discovery of sulfated sterols from marine invertebrates as a new class of marine natural antagonists of farnesoid-X-receptor.

Abstract

We report the biochemical characterization of sulfated polyhydroxysterols isolated from marine invertebrates as potent antagonists of farnesoid-X-receptor (FXR), a ligand-regulated transcription factor involved in the regulation of lipid and glucose homeostasis in mammals. Molecular characterization of a library of sulfated polyhydroxysteroids resulted in… (More)
DOI: 10.1021/jm101336m

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@article{Sepe2011DiscoveryOS, title={Discovery of sulfated sterols from marine invertebrates as a new class of marine natural antagonists of farnesoid-X-receptor.}, author={Valentina Sepe and Giuseppe Bifulco and Barbara Renga and Claudio D'Amore and Stefano Fiorucci and Angela Zampella}, journal={Journal of medicinal chemistry}, year={2011}, volume={54 5}, pages={1314-20} }