Discovery of small molecule inhibitors of West Nile virus using a high-throughput sub-genomic replicon screen.

@article{Gu2006DiscoveryOS,
  title={Discovery of small molecule inhibitors of West Nile virus using a high-throughput sub-genomic replicon screen.},
  author={Baohua Gu and Serguey Ouzunov and Liguan Wang and Peter Mason and Nigel Bourne and Andy Cuconati and Timothy M. Block},
  journal={Antiviral research},
  year={2006},
  volume={70 2},
  pages={
          39-50
        }
}
West Nile virus (WNV) is a positive-sense, single-stranded RNA virus of the family Flaviviridae. WNV persistently infects insect cells, but can causes acute cytopathic infection of mammalian cells and is an etiologic agent of viral encephalitis in humans. By using a cell line expressing a WNV subgenomic replicon [Rossi, S.L., Zhao, Q., O'Donnell, V.K., Mason, P.W., 2005. Adaptation of West Nile virus replicons to cells in culture and use of replicon-bearing cells to probe antiviral action… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 16 CITATIONS

Identification of novel small-molecule inhibitors of West Nile virus infection.

  • Journal of virology
  • 2007
VIEW 4 EXCERPTS
CITES BACKGROUND & METHODS
HIGHLY INFLUENCED