Discovery of small-molecule HIV-1 fusion and integrase inhibitors oleuropein and hydroxytyrosol: part II. integrase inhibition.

@article{LeeHuang2007DiscoveryOS,
  title={Discovery of small-molecule HIV-1 fusion and integrase inhibitors oleuropein and hydroxytyrosol: part II. integrase inhibition.},
  author={Sylvia Lee-Huang and Philip Lin Huang and Dawei Zhang and Jae Wook Lee and Ju Bao and Yongtao Sun and Y. -S. Chang and John H Zhang and Paul Lee Huang},
  journal={Biochemical and biophysical research communications},
  year={2007},
  volume={354 4},
  pages={879-84}
}
We report molecular modeling and functional confirmation of Ole and HT binding to HIV-1 integrase. Docking simulations identified two binding regions for Ole within the integrase active site. Region I encompasses the conserved D64-D116-E152 motif, while region II involves the flexible loop region formed by amino acid residues 140-149. HT, on the other hand… CONTINUE READING