Discovery of selective small molecule type III phosphatidylinositol 4-kinase alpha (PI4KIIIα) inhibitors as anti hepatitis C (HCV) agents.

@article{Leivers2014DiscoveryOS,
  title={Discovery of selective small molecule type III phosphatidylinositol 4-kinase alpha (PI4KIIIα) inhibitors as anti hepatitis C (HCV) agents.},
  author={Anna L Leivers and Matthew D Tallant and J Brad Shotwell and Scott Dickerson and Martin R Leivers and Octerloney B. MCDONALD and Jeff Gobel and Katrina L. Creech and Susan L Strum and Amanda Mathis and Sabrinia Rogers and Chris B. Moore and J{\'a}nos Boty{\'a}nszki},
  journal={Journal of medicinal chemistry},
  year={2014},
  volume={57 5},
  pages={2091-106}
}
Hepatitis C virus (HCV) assembles many host cellular proteins into unique membranous replication structures as a prerequisite for viral replication, and PI4KIIIα is an essential component of these replication organelles. RNA interference of PI4KIIIα results in a breakdown of this replication complex and cessation of HCV replication in Huh-7 cells. PI4KIIIα is a lipid kinase that interacts with the HCV nonstructural 5A protein (NS5A) and enriches the HCV replication complex with its product… CONTINUE READING

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