Discovery of regulatory elements in vertebrates through comparative genomics

@article{Prakash2005DiscoveryOR,
  title={Discovery of regulatory elements in vertebrates through comparative genomics},
  author={Amol Prakash and Martin Tompa},
  journal={Nature Biotechnology},
  year={2005},
  volume={23},
  pages={1249-1256}
}
We have analyzed issues of reliability in studies in which comparative genomic approaches have been applied to the discovery of regulatory elements at a genome-wide level in vertebrates. We point out some potential problems with such studies, including difficulties in accurately identifying orthologous promoter regions. Many of these subtle analytical problems have become apparent only when studying the more complex vertebrate genomes. By determining motif reliability, we compared existing… CONTINUE READING

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