Discovery of pyrazolthiazoles as novel and potent inhibitors of bacterial gyrase.

Abstract

Bacterial DNA gyrase is an attractive target for the investigation of new antibacterial agents. Inhibitors of the GyrB subunit, which contains the ATP-binding site, are described in this communication. Novel, substituted 5-(1H-pyrazol-3-yl)thiazole compounds were identified as inhibitors of bacterial gyrase. Structure-guided optimization led to greater… (More)
DOI: 10.1016/j.bmcl.2010.03.052

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Cite this paper

@article{Ronkin2010DiscoveryOP, title={Discovery of pyrazolthiazoles as novel and potent inhibitors of bacterial gyrase.}, author={Steven M Ronkin and Michael Badia and Steve F Bellon and Anne-Laure Grillot and Christian Gross and T Grossman and Nagraj Mani and Jonathan D Parsons and Dean Stamos and Martin Trudeau and Yunyi Wei and Paul S. Charifson}, journal={Bioorganic & medicinal chemistry letters}, year={2010}, volume={20 9}, pages={2828-31} }