Discovery of putative pancreatic cancer biomarkers using subcellular proteomics.

  title={Discovery of putative pancreatic cancer biomarkers using subcellular proteomics.},
  author={Kimberly Q. McKinney and Yong-Yook Lee and Hyun-Su Choi and Gale Groseclose and David A. Iannitti and John B Martinie and Mark W. Russo and Deborah H. Lundgren and David K. Han and Herbert L. Bonkovsky and Sun-Il Hwang},
  journal={Journal of proteomics},
  volume={74 1},
Pancreatic cancer (PC) is a highly aggressive disease that frequently remains undetected until it has progressed to an advanced, systemic stage. Successful treatment of PC is hindered by the lack of early detection. The application of proteomic analysis to PC combined with subcellular fractionation has introduced new possibilities in the field of biomarker discovery. We utilized matched pairs of pancreas tumor and non-tumor pancreas from patients undergoing tumor resection. The tissues were… CONTINUE READING


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