Discovery of potent small-molecule inhibitors of multidrug-resistant Plasmodium falciparum using a novel miniaturized high-throughput luciferase-based assay.

@article{Lucumi2010DiscoveryOP,
  title={Discovery of potent small-molecule inhibitors of multidrug-resistant Plasmodium falciparum using a novel miniaturized high-throughput luciferase-based assay.},
  author={Edinson Lucumi and Claire Darling and Hyunil Jo and Andrew D. Napper and Rajesh Chandramohanadas and Nicholas I. Fisher and Alison E. Shone and Huiyan Jing and Stephen A Ward and Giancarlo A Biagini and William F. DeGrado and Scott L. Diamond and Doron C. Greenbaum},
  journal={Antimicrobial agents and chemotherapy},
  year={2010},
  volume={54 9},
  pages={3597-604}
}
Malaria is a global health problem that causes significant mortality and morbidity, with more than 1 million deaths per year caused by Plasmodium falciparum. Most antimalarial drugs face decreased efficacy due to the emergence of resistant parasites, which necessitates the discovery of new drugs. To identify new antimalarials, we developed an automated 384-well plate screening assay using P. falciparum parasites that stably express cytoplasmic firefly luciferase. After initial optimization, we… CONTINUE READING
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