Discovery of potent and selective 8-fluorotriazolopyridine c-Met inhibitors.

Abstract

The overexpression of c-Met and/or hepatocyte growth factor (HGF), the amplification of the MET gene, and mutations in the c-Met kinase domain can activate signaling pathways that contribute to cancer progression by enabling tumor cell proliferation, survival, invasion, and metastasis. Herein, we report the discovery of 8-fluorotriazolopyridines as… (More)
DOI: 10.1021/jm501913a

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