Discovery of potent 1H-imidazo[4,5-b]pyridine-based c-Met kinase inhibitors via mechanism-directed structural optimization.

@article{An2015DiscoveryOP,
  title={Discovery of potent 1H-imidazo[4,5-b]pyridine-based c-Met kinase inhibitors via mechanism-directed structural optimization.},
  author={Xiao-De An and Hongyan Liu and Zhong-Liang Xu and Yi Jin and Xia Peng and Yingming Yao and Mei-yu Geng and Ya-Qiu Long},
  journal={Bioorganic & medicinal chemistry letters},
  year={2015},
  volume={25 3},
  pages={708-16}
}
Starting from our previously identified novel c-Met kinase inhibitors bearing 1H-imidazo[4,5-h][1,6]naphthyridin-2(3H)-one scaffold, a global structural exploration was conducted to furnish an optimal binding motif for further development, directed by the enzyme inhibitory mechanism. First round SAR study picked two imidazonaphthyridinone frameworks with 1… CONTINUE READING