Discovery of novel positive allosteric modulators of the metabotropic glutamate receptor 5 (mGlu5).


Novel in vitro mGlu(5) positive allosteric modulators with good potency, solubility, and low lipophilicity are described. Compounds were identified which did not rely on the phenylacetylene and carbonyl functionalities previously observed to be required for in vitro activity. Investigation of the allosteric binding requirements of a series of… (More)
DOI: 10.1016/j.bmcl.2011.01.027


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