Discovery of novel peptides targeting pro-atherogenic endothelium in disturbed flow regions -Targeted siRNA delivery to pro-atherogenic endothelium in vivo

@inproceedings{Chung2016DiscoveryON,
  title={Discovery of novel peptides targeting pro-atherogenic endothelium in disturbed flow regions -Targeted siRNA delivery to pro-atherogenic endothelium in vivo},
  author={Jihwa Chung and Hyunbo Shim and Kwanchang Kim and Duhwan Lee and Won Jong Kim and Dong Il Kang and Sang Won Kang and Hanjoong Jo and Kihwan Kwon},
  booktitle={Scientific reports},
  year={2016}
}
Atherosclerosis occurs preferentially in arterial regions exposed to disturbed blood flow. Targeting these pro-atherogenic regions is a potential anti-atherogenic therapeutic approach, but it has been extremely challenging. Here, using in vivo phage display approach and the partial carotid ligation model of flow-induced atherosclerosis in mouse, we identified novel peptides that specifically bind to endothelial cells (ECs) exposed to disturbed flow condition in pro-atherogenic regions. Two… CONTINUE READING
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