Discovery of novel inhibitors of Trypanosoma cruzi trans-sialidase from in silico screening.

@article{Neres2009DiscoveryON,
  title={Discovery of novel inhibitors of Trypanosoma cruzi trans-sialidase from in silico screening.},
  author={Jo{\~a}o Neres and Mark L. Brewer and Laura Ratier and Horacio Botti and Alejandro Buschiazzo and Philip N Edwards and Paul N. Mortenson and Michael H. Charlton and Pedro M Alzari and Alberto Carlos C Frasch and Richard A. Bryce and Kenneth T. Douglas},
  journal={Bioorganic & medicinal chemistry letters},
  year={2009},
  volume={19 3},
  pages={589-96}
}
trans-Sialidase from Trypanosoma cruzi (TcTS) has emerged as a potential drug target for treatment of Chagas disease. Here, we report the results of virtual screening for the discovery of novel TcTS inhibitors, which targeted both the sialic acid and sialic acid acceptor sites of this enzyme. A library prepared from the Evotec database of commercially… CONTINUE READING