Discovery of novel inducers of cellular differentiation using HL-60 promyelocytic cells.

@article{MataGreenwood2001DiscoveryON,
  title={Discovery of novel inducers of cellular differentiation using HL-60 promyelocytic cells.},
  author={Eugenia Mata-Greenwood and Ai Ito and Hans E Westenburg and Baoliang Cui and Rajendra G. Mehta and A Douglas Kinghorn and John M Pezzuto},
  journal={Anticancer research},
  year={2001},
  volume={21 3B},
  pages={1763-70}
}
Non-physiological inducers of terminal differentiation have been used as novel therapies for the prevention and therapy of cancer. We have used cultured HL-60 promyelocytic cells to monitor differentiation, proliferation and cell death events as induced by a large set of extracts derived from plants. Screening of more than 1400 extracts led to the discovery… CONTINUE READING