Discovery of novel heterocyclic factor VIIa inhibitors.


Structure-activity relationships and binding mode of novel heterocyclic factor VIIa inhibitors will be described. In these inhibitors, a highly basic 5-amidinoindole moiety has been successfully replaced with a less basic 5-aminopyrrolo[3,2-b]pyridine scaffold.

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@article{Rai2006DiscoveryON, title={Discovery of novel heterocyclic factor VIIa inhibitors.}, author={Roopa Rai and Aleksandr Kolesnikov and Paul A. Sprengeler and Steven Torkelson and Tony L Ton and Bradley A Katz and Christine Luong Yu and John S. Hendrix and William D Shrader and Robin Stephens and Ronnell Cabuslay and Ellen Sanford and Wendy B. Young}, journal={Bioorganic & medicinal chemistry letters}, year={2006}, volume={16 8}, pages={2270-3} }