Discovery of novel fibroblast growth factor receptor 1 kinase inhibitors by structure-based virtual screening.

@article{Ravindranathan2010DiscoveryON,
  title={Discovery of novel fibroblast growth factor receptor 1 kinase inhibitors by structure-based virtual screening.},
  author={Krishna P Ravindranathan and Valsan Mandiyan and Anil R. Ekkati and Jae Hyun Bae and Joseph E. Schlessinger and William L. Jorgensen},
  journal={Journal of medicinal chemistry},
  year={2010},
  volume={53 4},
  pages={
          1662-72
        }
}
Fibroblast growth factors (FGFs) play important roles in embryonic development, angiogenesis, wound healing, and cell proliferation and differentiation. In search of inhibitors of FGFR1 kinase, 2.2 million compounds were docked into the ATP binding site of the protein. A co-crystal structure, which shows two alternative conformations for the nucleotide binding loop, is reported. Docking was performed on both conformations and, ultimately, 23 diverse compounds were purchased and assayed… CONTINUE READING
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