Discovery of novel 3-(hydroxyalkoxy)-2-alkylchromen-4-one analogs as interleukin-5 inhibitors.

@article{Boggu2017DiscoveryON,
  title={Discovery of novel 3-(hydroxyalkoxy)-2-alkylchromen-4-one analogs as interleukin-5 inhibitors.},
  author={Pulla Reddy Boggu and Eeda Venkateswararao and M. Kamala Palaniappa Manickam and Young Soo Kim and Sang-Hun Jung},
  journal={European journal of medicinal chemistry},
  year={2017},
  volume={139},
  pages={290-304}
}
A series of novel chromen-4-one analogs 9a-d and 10a-u was designed, synthesized and evaluated for their IL-5 inhibitory activity. Most of the chromen-4-one analogs showed strong inhibitory activity in low micro molar potency. Among them, 5-(cyclohexylmethoxy)-3-(3-hydroxypropoxy)-2-isopropyl-4H-chromen-4-one (10t, 90.0% inhibition at 30 μM, IC50 = 5.5 μM… CONTINUE READING