Discovery of novel CDK8 inhibitors using multiple crystal structures in docking-based virtual screening.

Abstract

The cyclin dependent kinase CDK8, along with Med12 and Med13, form the kinase module of the Mediator complex. CDK8 expression associates with the activation of β-catenin in colon and gastric cancers. Herein, we applied docking-based virtual screening (VS) using the multiple crystal structures to identify several potent CDK8 inhibitors. The appropriate use… (More)
DOI: 10.1016/j.ejmech.2017.02.020

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Cite this paper

@article{Wang2017DiscoveryON, title={Discovery of novel CDK8 inhibitors using multiple crystal structures in docking-based virtual screening.}, author={Taijin Wang and Zhuang Yang and Yongguang Zhang and Wei Yan and Fang Wang and Linhong He and Yuanyuan Zhou and Lijuan Chen}, journal={European journal of medicinal chemistry}, year={2017}, volume={129}, pages={275-286} }