Discovery of non-ETS gene fusions in human prostate cancer using next-generation RNA sequencing.

@article{Pflueger2011DiscoveryON,
  title={Discovery of non-ETS gene fusions in human prostate cancer using next-generation RNA sequencing.},
  author={Dorothee Pflueger and St{\'e}phane Terry and Andrea Sboner and Lukas Habegger and Raquel Esgueva and Pei-Chun Lin and Maria Svensson and Naoki Kitabayashi and Benjamin J. Moss and Theresa Macdonald and Xuhong Cao and Terrence R. Barrette and Ashutosh Tewari and Mark S. Chee and Arul M. Chinnaiyan and David S. Rickman and Francesca Demichelis and Mark B Gerstein and Mark A. Rubin},
  journal={Genome research},
  year={2011},
  volume={21 1},
  pages={56-67}
}
Half of prostate cancers harbor gene fusions between TMPRSS2 and members of the ETS transcription factor family. To date, little is known about the presence of non-ETS fusion events in prostate cancer. We used next-generation transcriptome sequencing (RNA-seq) in order to explore the whole transcriptome of 25 human prostate cancer samples for the presence of chimeric fusion transcripts. We generated more than 1 billion sequence reads and used a novel computational approach (FusionSeq) in order… CONTINUE READING