Discovery of new senolytics using machine learning

  title={Discovery of new senolytics using machine learning},
  author={Vanessa Smer-Barreto and Andrea Quintanilla and Richard Elliot and John C. Dawson and Jiugeng Sun and Neil O. Carragher and Juan Carlos Acosta and Diego A. Oyarz{\'u}n},
Cellular senescence is a stress response characterised by a permanent cell cycle arrest and a proinflammatory secretome. In addition to its tumour suppressor role, senescence is involved in ageing and promotes many disease processes such as cancer, type 2 diabetes, osteoarthritis, and SARS-CoV-2 infection. There is a growing interest in therapies based on targeted elimination of senescent cells, yet so far only a few such senolytics are known, partly due to the poor grasp of the molecular…