Discovery of new chemotype dipeptidyl peptidase IV inhibitors having (R)-3-amino-3-methyl piperidine as a pharmacophore.

@article{Nishio2010DiscoveryON,
  title={Discovery of new chemotype dipeptidyl peptidase IV inhibitors having (R)-3-amino-3-methyl piperidine as a pharmacophore.},
  author={Yukihiro Nishio and Hidenori Kimura and Shinya Tosaki and Eiji Sugaru and Mutsuko Sakai and Masakuni Horiguchi and Yumi Masui and Michiko Ono and Tsutomu Nakagawa and Hiroyuki Nakahira},
  journal={Bioorganic & medicinal chemistry letters},
  year={2010},
  volume={20 24},
  pages={7246-9}
}
Structures containing the (R)-3-amino-3-methyl piperidine unit as a new pharmacophore moiety have been shown to possess moderate inhibitory activity for DPP-4 with good pharmacokinetics profile. One of these compounds was found to have good oral bioavailability and PK/PD profile in ZF-rat.