Discovery of natural product chemopreventive agents utilizing HL-60 cell differentiation as a model.

@article{Suh1995DiscoveryON,
  title={Discovery of natural product chemopreventive agents utilizing HL-60 cell differentiation as a model.},
  author={Nina Suh and Lumonadio Luyengi and Harry H. S. Fong and A Douglas Kinghorn and John M Pezzuto},
  journal={Anticancer research},
  year={1995},
  volume={15 2},
  pages={233-9}
}
Terminal differentiation of human promyelocytic leukemia (HL-60) cells can be induced by a variety of chemical agents and this process can be monitored readily by the generation of morphologically, histochemically, and functionally mature granulocytes and monocytes/macrophages. The availability of this model has heightened interest in the possible therapeutic role of inducers of myeloid differentiation for the treatment of leukemia and other neoplasms. In addition, however, potent cancer… CONTINUE READING

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