Discovery of multifold modified sialosides as human CD22/Siglec-2 ligands with nanomolar activity on B-cells.

@article{Prescher2014DiscoveryOM,
  title={Discovery of multifold modified sialosides as human CD22/Siglec-2 ligands with nanomolar activity on B-cells.},
  author={Horst Prescher and Astrid Schweizer and Elena Kuhfeldt and Lars Nitschke and Reinhard Brossmer},
  journal={ACS chemical biology},
  year={2014},
  volume={9 7},
  pages={
          1444-50
        }
}
Sialic acids are abundant in higher domains of life and lectins recognizing sialosaccharides are heavily involved in the regulation of the human immune system. Modified sialosides are useful tools to explore the functions of those lectins, especially members of the Siglec (sialic acid binding immunoglobulin like lectin) family. Here we report design, synthesis, and affinity evaluation of novel sialoside classes with combined modification at positions 2, 4, and 9 or 2, 3, 4, and 9 of the sialic… CONTINUE READING
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