Discovery of monoclonal antibodies cross-reactive to novel subserotypes of K. pneumoniae O3

  title={Discovery of monoclonal antibodies cross-reactive to novel subserotypes of K. pneumoniae O3},
  author={Luis M Guachalla and Katarina Stojkovic and Katharina Hartl and Marta Kaszowska and Yadhu Kumar and Benjamin Wahl and Tobias Paprotka and Eszter Nagy and Jolanta Lukasiewicz and G{\'a}bor Nagy and Val{\'e}ria Szij{\'a}rt{\'o}},
  booktitle={Scientific Reports},
Klebsiella pneumoniae is responsible for nosocomial infections causing significant morbidity and mortality. Treatment of newly emerging multi-drug resistant strains is hampered due to severely limited antibiotic choices. Passive immunization targeting LPS O-antigens has been proposed as an alternative therapeutic option, given the limited variability of Klebsiella O-antigens. Here we report that the O3 serogroup, previously considered to have uniform O-antigen built of mannan, represents three… CONTINUE READING
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