Discovery of membrane active benzimidazole quinolones-based topoisomerase inhibitors as potential DNA-binding antimicrobial agents.

@article{Zhang2016DiscoveryOM,
  title={Discovery of membrane active benzimidazole quinolones-based topoisomerase inhibitors as potential DNA-binding antimicrobial agents.},
  author={Ling Zhang and Dinesh Addla and Jeyakkumar Ponmani and Ao Wang and Dan Xie and Yanan Wang and Shao-Lin Zhang and Rong-Xia Geng and Gui-Xin Cai and Shuo Li and Cheng-He Zhou},
  journal={European journal of medicinal chemistry},
  year={2016},
  volume={111},
  pages={160-82}
}
A series of novel benzimidazole quinolones as potential antimicrobial agents were designed and synthesized. Most of the prepared compounds exhibited good or even stronger antimicrobial activities in comparison with reference drugs. The most potent compound 15m was membrane active and did not trigger the development of resistance in bacteria. It not only… CONTINUE READING