Discovery of indolotryptoline antiproliferative agents by homology-guided metagenomic screening.

@article{Chang2013DiscoveryOI,
  title={Discovery of indolotryptoline antiproliferative agents by homology-guided metagenomic screening.},
  author={Fang-Yuan Chang and Sean F. Brady},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2013},
  volume={110 7},
  pages={2478-83}
}
Natural product discovery by random screening of broth extracts derived from cultured bacteria often suffers from high rates of redundant isolation, making it ever more challenging to identify novel biologically interesting natural products. Here we show that homology-based screening of soil metagenomes can be used to specifically target the discovery of… CONTINUE READING