Discovery of indirubin derivatives as new class of DRAK2 inhibitors from high throughput screening.

Abstract

DRAK2 is a serine/threonine kinase belonging to the death-associated protein kinase (DAPK) family and has emerged as a promising drug target for the treatment of autoimmune diseases and cancers. To identify small molecule inhibitors for DRAK2, we performed a high throughput screening campaign using in-house chemical library and identified indirubin-3… (More)
DOI: 10.1016/j.bmcl.2016.03.111

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