Discovery of genetic biomarkers contributing to variation in drug response of cytidine analogues using human lymphoblastoid cell lines

@inproceedings{Li2013DiscoveryOG,
  title={Discovery of genetic biomarkers contributing to variation in drug response of cytidine analogues using human lymphoblastoid cell lines},
  author={Liang Li and Brooke L. Fridley and Krishna R. Kalari and Nifang Niu and Gregory D. Jenkins and Anthony J Batzler and Ryan Abo and Daniel J. Schaid and Liewei Wang},
  booktitle={BMC Genomics},
  year={2013}
}
Two cytidine analogues, gemcitabine and cytosine arabinoside (AraC), are widely used in the treatment of a variety of cancers with a large individual variation in response. To identify potential genetic biomarkers associated with response to these two drugs, we used a human lymphoblastoid cell line (LCL) model system with extensive genomic data, including 1.3 million SNPs and 54,000 basal expression probesets to perform genome-wide association studies (GWAS) with gemcitabine and AraC IC50… CONTINUE READING
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Somatic mutations and germline sequence variants in the expressed tyrosine Li et al

  • MH Tomasson, Z Xiang, +22 authors TJ Ley
  • BMC Genomics
  • 2014
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