Discovery of dominant and dormant genes from expression data using a novel generalization of SNR for multi-class problems

@article{Tsai2008DiscoveryOD,
  title={Discovery of dominant and dormant genes from expression data using a novel generalization of SNR for multi-class problems},
  author={Yu-Shuen Tsai and Chin-Teng Lin and George C. Tseng and I-Fang Chung and Nikhil R. Pal},
  journal={BMC Bioinformatics},
  year={2008},
  volume={9},
  pages={425 - 425}
}
The Signal-to-Noise-Ratio (SNR) is often used for identification of biomarkers for two-class problems and no formal and useful generalization of SNR is available for multiclass problems. We propose innovative generalizations of SNR for multiclass cancer discrimination through introduction of two indices, Gene Dominant Index and Gene Dormant Index (GDIs). These two indices lead to the concepts of dominant and dormant genes with biological significance. We use these indices to develop… CONTINUE READING
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