Discovery of distinct protein profiles specific for lung tumors and pre-malignant lung lesions by SELDI mass spectrometry.

@article{Zhukov2003DiscoveryOD,
  title={Discovery of distinct protein profiles specific for lung tumors and pre-malignant lung lesions by SELDI mass spectrometry.},
  author={Tatyana Zhukov and Roy A Johanson and Alan B Cantor and Robert A. Clark and Melvyn S. Tockman},
  journal={Lung cancer},
  year={2003},
  volume={40 3},
  pages={267-79}
}
OBJECTIVES Early lung cancer detection and treatment remain a challenge. The efficacy of surface-enhanced laser desorption/ionization (SELDI) technology in lung cancer detection, has not been defined. This study identifies specific protein peak patterns in malignant lung tumors, and in pre-malignant airways epithelium showing neoplastic transformation. METHODS Lung tumor specimens taken from patients participating in a lung cancer screening study (H. Lee Moffitt Cancer Center, Tampa, FL) were… CONTINUE READING

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