Discovery of diphenylmethane analogs as anti-bovine diarrhea viral agents.

@article{Hosoda2009DiscoveryOD,
  title={Discovery of diphenylmethane analogs as anti-bovine diarrhea viral agents.},
  author={Shinnosuke Hosoda and Hiroshi Aoyama and Yukinori Goto and Mohammed T A Salim and Mika Okamoto and Mariko Hashimoto and Masanori Baba and Yuichi Hashimoto},
  journal={Bioorganic & medicinal chemistry letters},
  year={2009},
  volume={19 12},
  pages={3157-61}
}
Based on antiviral screening of our diphenylmethane derivatives prepared as steroid substitutes, we identified a 1,1-diphenylcyclobutane analog (9) and two diethyldiphenylsilane analogs (12 and 13) as superior lead compounds with potent anti-bovine viral diarrhea virus (BVDV) activity, having 50% effective concentration (EC(50): based on reduction of BVDV… CONTINUE READING