Discovery of cryptic polyketide metabolites from dermatophytes using heterologous expression in Aspergillus nidulans.

@article{Yin2013DiscoveryOC,
  title={Discovery of cryptic polyketide metabolites from dermatophytes using heterologous expression in Aspergillus nidulans.},
  author={Wenbing Yin and Yit Heng Chooi and Adam R. Smith and Ralph A. Cacho and Youcai Hu and Theodore C. White and Yi Tang},
  journal={ACS synthetic biology},
  year={2013},
  volume={2 11},
  pages={629-34}
}
Dermatophytes belonging to the Trichophyton and Arthroderma genera cause skin infections in humans and animals. From genome sequencing data, we mined a conserved gene cluster among dermatophytes that are homologous to one that produces an immunosuppressive polyketide in Aspergillus fumigatus. Using a recombination-based cloning strategy in yeast, we… CONTINUE READING