Discovery of cancer biomarkers through the use of mouse models.

@article{Kuick2007DiscoveryOC,
  title={Discovery of cancer biomarkers through the use of mouse models.},
  author={Rork Kuick and David E. Misek and David J Monsma and Craig Paul Webb and Hong Wang and Kelli J Peterson and Michael Pisano and Gilbert S. Omenn and Samir M Hanash},
  journal={Cancer letters},
  year={2007},
  volume={249 1},
  pages={40-8}
}
Although our understanding of the molecular pathogenesis of common types of cancer has improved considerably, the development of effective strategies for cancer diagnosis and treatment have lagged behind. Mouse models of cancer potentially represent an efficient means for uncovering diagnostic markers as genetic alterations associated with human tumors can be engineered in mice. In addition, defined stages of tumor development, breeding conditions, and blood sampling can all be controlled and… CONTINUE READING

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